Ursolic Acid in DermCareMD Anti Aging Skin Care Products and Skin Care Treatments

Ursolic Acid in DermCareMD Anti Aging Skin Care Products and Skin Care Treatments

Ursolic acid is a very potent anti-inflammatory and anti-cancer compound it also reduces wrinkles and increases skin collagen content.

Ursolic acid

• Reduces wrinkles.
• Increases skin collagen content.
• Increases ceramide production to reduce drying and flaking.
• Potent anti-inflammatory and anti-cancer activity.
• Kills skin germs.

Ursolic acid is a very potent anti-inflammatory and anti-cancer compound, which has additional uniqueproperties for your skin: it reduces wrinkles. ursolic acid increases skin collagen content by increasing itsproduction by skin fibroblast cells in the dermis (your deeper skin layer), as well as increasing the ceramide(natural moisture barrier) content of your epidermis (superficial skin layer). Ceramides are found in highconcentration in youthful skin and are significantly diminished in aged skin. High amounts of collagen and ceramides decrease skin wrinkling and reduce its dry, flaking outer surface (stratum corneum).

And unlike Retinoids, ursolic acid increases the ceramide content of human keratinocytes (epidermal cells). Ursolic acid is found in high percentages in extracts of the herbs: rosemary, eriobotrya japonica calli,mallotus peltatus, perilla frutescens thymus broussonettii, and thymus willdenowil. In fact, the most activebiological compound in all these herbs is ursolic acid.

Anti-inflammatory and anti-cancer activity

Marked anti-inflammatory effect, plus a potent inhibitory effect on the Epstein-Barr virus antigen induction(93%), and exhibited strong anti-tumor promoting activity in an in-vivo two-stage carcinogenesis test using DMBA as aninitiator and TPA as a promoter (both are carcinogens). And showed an inhibitory effect comparable toEGCG of Green Tea on the activation of Epstein-Barr virus early antigen induced by TPA. 10 ursolic acid isa potent anti-inflammatory agent.

Ursolic acid could be an encouraging compound in the treatment or prevention of skin cancer and may represent apromising new anti-cancer agent in the treatment of melanoma.
Topical application of ursolic acid inhibited TPA-induced inflammation, ornithine decarboxylase activity, and tumorpromotion.Topical application of ursolic acid together with TPA (carcinogen) twice weekly for 20 weeks to DMBA initiated(carcinogen pre-treated) mice inhibited the number of tumors per mouse by 61%.

Ursolic Acid Suppresses UVA caused photo-aging Ursolic acid: prevents premature aging of the skin. Ursolic acid significantly suppressed UVA-induced reactiveoxygen species production and lipid peroxidation. Pretreatment with ursolic acid significantly reduced the UV-A-inducedactivation and expression of MMP-2. In addition, UVA-induced enhanced expression of p53, a hallmark of UV-inducedDNA damage and cell death, was also significantly inhibited by pretreatment with ursolic acid. Taken together, these resultssuggest that ursolic acid may be an effective inhibitor of UVA-modulated signal transduction pathways in human skin cells.These results further suggest that this agent may be useful in the prevention of UVA-induced photo-aging.